Infertility Herbs, Spices and Male Infertility

To counter infertility herbs and spices have become more and more important as the incidence of male infertility has increased dramatically over the past century. Until recently the cause of this phenomenon has been something of a mystery. However we now know that environmental factors such as synthetic estrogens, pesticides, heavy metals and other pollutants are responsible for this problem.

Main cause of male inferility

These agents inflict oxidative damage on the highly susceptible developing sperm to such an extent that they are now the leading cause of male infertility. The good news is that the use of supplementary dietary antioxidants to treat oxidative stress-induced male infertility is yielding very good results.

Until recently conditions such as varicocele, undescended testes, infections, obstructive lesions, cystic fibrosis, trauma, and tumors were the only known causes of male infertility. Those men who did not fall into any of these groups were described as having "idiopathic" infertility as the cause has only recently been identified.

However, over the past decade it has become clear that the principal cause of idiopathic male infertility is an underlying pathological condition known as oxidative stress.

Oxidative stress and free radical damage

Oxidative stress is a well known biological state that occurs when there is an imbalance between the body's production of excessive reactive oxygen species (also known as free radicals) and an insufficiency of internal and dietary-derived antioxidants to counter the adverse effects of the these potentially harmful molecules.

Although all cells may be damaged during episodes of oxidative stress, spermatozoa are particularly susceptible to free radical damage.

Reactive oxygen species (ROS) are environmental pollutants as well as by-products of the body's energy production and other cellular activities. Although some cellular ROS do fulfill important physiological functions when produced in excess they can affect both the quality and quantity of sperm.

Under normal circumstances seminal fluid contains antioxidants that control the damaging effects of ROS; but if excessive quantities of the latter are produced an imbalance occurs and the ROS inflict damage to the sperm cell walls and sperm DNA. This leads to the production of poor quality sperm and results in infertility.

Moreover, such DNA-damaged sperm may cause miscarriages, produce offspring with conditions such as achondroplasia (dwarfism) and trigger childhood cancers.

Infection and inflammation

Two of the aggravating factors associated with idiopathic male infertility are infection and inflammation. Even low grade, "hidden" genito-urinary infections cause inflammation and an associated increase in the number of leukocytes (white blood cells) in the male reproductive tissues.

Both contaminating leukocytes and abnormal sperm cells contribute to an increase in the production of ROS and oxidative stress that further compromises normal spermatogenesis.

Other causes of oxidative stress

Other causes of oxidative stress associated with male infertility are smoking, aging, pesticides, exogenous estrogens, heavy metals and diseases such as diabetes.

Nutritional management of idiopathic infertility

However it is important to note that ROS can have both beneficial and detrimental effects on spermatozoa. The ratio of quantities of ROS produced to those neutralized by antioxidant compounds will decide whether a given sperm function will be helped or hindered.

As various antioxidant compounds work at different stages of the oxidative process it is unlikely that taking large doses of one "strong" antioxidant alone will make much impact. In fact large doses of any antioxidant may actually aggravate the situation as certain ROS like hydrogen peroxide are essential signaling molecules without which normal immune function is compromised.

We recommend, therefore, that large doses of one or two antioxidant vitamins such as vitamin C, E and Beta-carotene are NOT taken without careful consideration.

Instead a diet rich in antioxidant containing foods such as spices, fruit and vegetables provide a wide variety of natural antioxidant compounds.

In fact spices have the greatest antioxidant activity of all food types (American Journal of Clinical Nutrition July 2006) For good general health and infertility herbs and spices should be added to all meals or taken as a balanced spice-based supplement.

To counter infertility herbs and spices are by far the best source of antioxidants and other important phytonutrients.

Spice supplement

Scientific references

2. An evidence-based perspective to the medical treatment of male infertility: a short review. Urol Int. 2009;82(2):125-9. Epub 2009 Mar 19.,Ghanem H, Shamloul R.

3. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.,Sheweita SA, Tilmisany AM, Al-Sawaf H.

4. Physiologic and pathologic levels of reactive oxygen species in neat semen of infertile men, Fertil Steril. 2008 Oct 18. Desai N, Sharma R, Makker K, Sabanegh E, Agarwal A.

5. Relative impact of oxidative stress on male reproductive function Curr Med Chem. 2001 Jun;8(7):851-62. Sikka SC.

6. Role of reactive oxygen species in male infertility. Urology. 1996 Dec;48(6):835-50. Sharma RK, Agarwal A.

7. Utility of oxidative stress test in the male infertility clinic Zhonghua Nan Ke Xue. 2002;8(1):1-9. Agarwal A, Saleh RA.